Help, I can’t POOP!” Essentials for Medication-Induced Constipation

A woman looking calm and healthy in her sunlit kitchen, drinking a glass of water as a first step to find relief from medication-induced constipation.

We have all been there, starting a new medication to help us feel better, only to have another medical problem arise. Constipation is one of the most common side effects of many medications and can lead to chronic constipation if not managed correctly.1

Constipation is defined as fewer than three bowel movements per week with additional symptoms, such as difficulty passing stool, hard stools, incomplete elimination or pain on elimination.2

If you are experiencing any of these, it’s time to get savvy and take charge

Essential Highlights

  • Understand what medications can cause constipation and what medications or supplements can help manage it
  • Understand how to address constipation side-effects
  • Learn pro-tips for prevention of constipation
  • Identify when to see your doctor

Identifying the Culprit

            When starting a new medication, ask the pharmacist or your physician if it will cause constipation. Be proactive and start constipation management before starting the medication if possible. Some of the top medication culprits causing constipation are in the following list:

  1. Iron supplementation
  2. Drugs used for Rheumatoid Arthritis and other inflammatory conditions, such as Humira
  3. Some migraine medicines, such as Aimovig
  4. Narcotic pain medications such as Morphine, Oxycodone, and Codeine
  5. Weight loss drugs such as Semiglutide and Orlistat
  6. Certain cancer drugs, such as Revlamid and Zejula
  7. Drugs to help phosphorus levels in chronic kidney disease such as Renvela
  8. Medications to treat schizophrenia, such as Clonazapine
  9. Bone health drugs such as Forteo and Alendronate sodium
  10. Smoking cessation drugs, such as Chantrix3

 This list is by no means all-inclusive, but it gives you an idea of just how many medications can cause constipation. Many adults are on several medications, worsening the problem. Regardless of the cause of your constipation, it is recommended that you use the stepwise approach below:

A healthy start to the day to help with constipation, featuring a tall glass of lemon water next to a bowl of Greek yogurt with fresh berries and granola.

Treating the Cause

Step 1

  1. Drink more water – We all forget to drink water on occasion, but water is key to maintaining a healthy colon. It should be plain water, not juice, soda or other flavored drinks. A good tip is to drink 8 ounces of water with each pill you take.
  2. Probiotics – Probiotics are the good bacteria that can help with digestion. They are found in many cultured foods, such as yogurt and cottage cheese, but are also available in supplement form. In one study in Parkinson’s patients, probiotics helped increase the frequency of bowel movements, but more studies are needed.4
  3. Bulk (fiber) and Osmotic laxatives – These are available at your pharmacy and help by bulking the stool and increasing water in the colon. They also help to decrease straining on elimination. Osmotic laxatives cause a shift in the water into the colon. Examples of these are sold under the brand names ‘Metamucil’ and ‘Miralax2

Step 2

  • Stool softeners and Stimulant laxatives – Use these as ‘rescue’ agents if Step 1 fails

These agents allow more water into the stool and cause the colon to move the stool along. Most are also available over the counter under brand names ‘Dulcolax’ and ‘Senokot’.2,4

Step 3

  • Prescription Medications – Yes, sometimes you need an additional prescription to manage a side-effect of a prescription. Talk to your physician if you are not able to manage the symptoms with over-the-counter medications.

Lifestyle Interventions

            When we are not feeling well, we tend not to move much. Lack of movement contributes to the constipation problem. Movement is needed for our bodies to process what we eat. Even a short walk around the house can help to move things along. In one study on constipation in 3300 women, the best results were achieved with moderate daily physical activity and fiber intake of 20 g per day.5 Give yourself a boost by taking a stroll today.

More About Probiotics and Other Dietary Hacks

            You’ve probably seen the advertisements for probiotic rich products to ‘help you stay regular’. What is the science behind these products, and do they work? Probiotics are the ‘good bacteria’ that are needed in your gut for digestion to occur and are found in many fermented products like yogurt, cottage cheese, and kefir. Think of them as tiny factories that break down waste. They are live organisms that may help with the ‘transit time’ from when food first enters to when it exits. They are not the only factor in how quickly food moves through our gut, though, which is why they sometimes are not enough when used alone. Some studies have shown that probiotics do help with transit time, while others show no change.4,6,7

            Many of us are shy about eating our daily dietary recommendations of 3 cups of whole fruits and vegetables. One hack to help with constipation is to increase your ‘roughage’ as much as possible. Salads and lightly steamed veggies are a great source of tasty fiber. Be sure to leave cooked veggies on the ‘al dente’ side to keep as much fiber as you can. If salad and broccoli are not your thing, think of popcorn as a good source of ‘roughage’, but be sure to go easy on the salt. Prunes and plums are also good sources of fiber that help with digestion. Smoothies with added fiber, such as chia seeds or flax meal, can also help you start your day right and help to keep you full. Drinking coffee can be a good laxative in some cases. In one abdominal surgery study, coffee helped with the time to first bowel movement over tea by 10 hours.8

            Some supplements can help with easing constipation. Magnesium citrate is one supplement that has many uses. It can help with sleep, muscle recovery and brain function, but also has a laxative side- effect and can help with constipation.9 Check with your doctor to be sure you can take magnesium supplements with your current medications.

When to Consult Your Doctor?

            Constipation is often a slow process, no pun intended. It can be difficult to know when to consult a physician. Here are some worrisome signs and symptoms that would need a trip to the physician or Emergency Room:

  1. Severe abdominal pain or tenderness, especially with straining.
  2. Changes in abdominal wall appearance, such as a bulge that wasn’t there before, or a pulsating mass.
  3. Bloody stools or change in stool appearance.
  4. Absence of stools for more than a week.
  5. Constipation with fever, nausea, vomiting or inability to pass any gas.
  6. Signs of severe abdominal bloating with a history of abdominal surgery.10

Final thoughts

            Constipation can be a normal occurrence or a side effect of medications, but being proactive can help you get it under control. If you know your medication is going to cause constipation, it is best to start increasing fiber a day or two before starting the medication. Finally – don’t suffer in silence, as sometimes ‘routine’ constipation can be a sign of bigger problems that should be addressed by your physician.

References

  1. Chang L, Chey WD, Imdad A, et al. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086-1106. doi:10.1053/j.gastro.2023.03.214
  2. Sadler K, Arnold F, Dean S. Chronic Constipation in Adults. Am Fam Physician. 2022;106(3):299-306.
  3. Li W, Liu C, Zhang Z, et al. Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system. Front Pharmacol. 2024;15:1443555. Published 2024 Sep 2. doi:10.3389/fphar.2024.1443555
  4. Du Y, Li Y, Xu X, et al. Probiotics for constipation and gut microbiota in Parkinson’s disease. Parkinsonism Relat Disord. 2022;103:92-97. doi:10.1016/j.parkreldis.2022.08.022
  5. Laurent Dukas, Walter C. Willett, Edward L. Giovannucci, Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women, The American Journal of Gastroenterology, Volume 98, Issue 8, 2003,Pages 1790-1796, ISSN 0002-9270, https://doi.org/10.1016/S0002-9270(03)00442-(https://www.sciencedirect.com/science/article/pii/S0002927003004428)
  6. Dimidi E, Christodoulides S, Scott SM, Whelan K. Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation. Adv Nutr. 2017;8(3):484-494. Published 2017 May 15. doi:10.3945/an.116.014407
  7. Bharucha AE, Lacy BE. Mechanisms, Evaluation, and Management of Chronic Constipation. Gastroenterology. 2020;158(5):1232-1249.e3. doi:10.1053/j.gastro.2019.12.034
  8. Gkegkes ID, Minis EE, Iavazzo C. Effect of Caffeine Intake on Postoperative Ileus: A Systematic Review and Meta-Analysis. Dig Surg. 2020;37(1):22-31. doi:10.1159/000496431
  9. Chan, Annie O.O. . (2012). A pilot study on the efficacy of Picolax given as a four-week course for the treatment of refractory constipation. Hong Kong Medical Journal, 18(5), 388–394
  10. Long B, Robertson J, Koyfman A. Emergency Medicine Evaluation and Management of Small Bowel Obstruction: Evidence-Based Recommendations. J Emerg Med. 2019;56(2):166-176. doi:10.1016/j.jemermed.2018.10.024
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Written by:

Janice Blumer, DO

Dr. Janice Blumer is a board-certified family physician (DO) with 34 years of experience in clinical practice and medical education. An author of numerous medical publications, she leverages her deep expertise in family and integrative medicine to ensure LowerMyRx content is accurate, clear, and expertly written.
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